BDBM774118 US12428433, Example 4

SMILES C[C@H]1Nc2ccn3ncc(c3n2)C(=O)N[C@H]2C[C@H](C2)Oc2ncccc21

InChI Key InChIKey=HCBACOBROXRJJP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 774118   

TargetHigh affinity nerve growth factor receptor(Human)
Scinnohub Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774118BDBM774118(US12428433, Example 4)
Affinity DataIC50: 320nMAssay Description:Inhibitory activities of the compound of the present application on three kinases TRKa, TRKA(G595R) and TRKC(G623R) were measured.2. Experimental Mat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Scinnohub Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774118BDBM774118(US12428433, Example 4)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activities of the compound of the present application on three kinases TRKa, TRKA(G595R) and TRKC(G623R) were measured.2. Experimental Mat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor [G623R](Homo sapiens (Human))
Scinnohub Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774118BDBM774118(US12428433, Example 4)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activities of the compound of the present application on three kinases TRKa, TRKA(G595R) and TRKC(G623R) were measured.2. Experimental Mat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent