BDBM774717 (E)-3-(4-(4-(5-(4- Aminopiperidin-1-yl)- 7-(4-cyano-3- fluorophenyl)imidazo [1,2-c]pyrimidin-8-yl)- 2- hydroxyphenoxy) methyl)phenyl)-N- hydroxyacrylamide hydrochloride::US20250304549, Example 23

SMILES N#Cc1ccc(-c2nc(N3CCC(N)CC3)n3ccnc3c2-c2ccc(OCc3ccc(/C=C/C(=O)NO)cc3)c(O)c2)cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 774717   

TargetLysine-specific histone demethylase 1A(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774717((E)-3-(4-(4-(5-(4- Aminopiperidin-1-yl)- 7-(4-cyan...)
Affinity DataIC50: 0.230nMAssay Description:The effect of the compounds on LSD1 enzyme activity was examined using the HTRF technique to assess the level of inhibition. Initially, a master solu...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774717((E)-3-(4-(4-(5-(4- Aminopiperidin-1-yl)- 7-(4-cyan...)
Affinity DataIC50: 74.4nMAssay Description:The effect of the compound on the enzymatic activity of pan-HDAC and two isoforms (HDAC1 and HDAC8) was examined using the HDAC-Glo I/II Assay and Sc...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774717((E)-3-(4-(4-(5-(4- Aminopiperidin-1-yl)- 7-(4-cyan...)
Affinity DataIC50: 198nMAssay Description:The effect of the compound on the enzymatic activity of pan-HDAC and two isoforms (HDAC1 and HDAC8) was examined using the HDAC-Glo I/II Assay and Sc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774717((E)-3-(4-(4-(5-(4- Aminopiperidin-1-yl)- 7-(4-cyan...)
Affinity DataIC50: 320nMAssay Description:The effect of the compound on the enzymatic activity of pan-HDAC and two isoforms (HDAC1 and HDAC8) was examined using the HDAC-Glo I/II Assay and Sc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent