BDBM77565 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-methylpiperazin-1-yl)ketone::US20250387388, Compound MDI-235

SMILES CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(C)CCN3C(=O)N3CCN(C)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1

InChI Key InChIKey=DQQXGBLWMGYGAL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 77565   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77565BDBM77565((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 0.100nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77565BDBM77565((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 0.270nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77565BDBM77565((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 0.570nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77565BDBM77565((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 1.39nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent