BDBM782847 Synthesis of (R)-4-(2-chloro-4-fluorophenyl)-7-(methyl(1-oxo-1-(piperidin-1-yl)propan-2-yl)amino)-2H-chromen-2-one, (R)-2-((4-(2-chloro-4-fluorophenyl)-2-oxo-2H-chromen-7-yl)(methyl)amino)-N,N-dimethylpropanamide::US20250326732, Example 45

SMILES C[C@H](C(=O)N1CCCCC1)N(C)c4ccc3c(c2ccc(F)cc2Cl)cc(=O)oc3c4

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 782847   

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782847(Synthesis of (R)-4-(2-chloro-4-fluorophenyl)-7-(me...)
Affinity DataIC50: 50nMAssay Description:The ability of some compounds of the present invention to inhibit POLRMT were determined in a homogeneous TR-FRET Assay using high-throughput screeni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent