BDBM782991 (S)-1-((R)-3-(4-(2-chloro-4-fluorophenyl)-2-oxo-2H-chromen-7-yl)-2-methylpropanoyl)piperidine-3-carboxylic acid::US20250326732, Example 187

SMILES C[C@H](Cc1ccc2c(-c3ccc(F)cc3Cl)cc(=O)oc2c1)C(=O)N1CCC[C@H](C(=O)O)C1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 782991   

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782991((S)-1-((R)-3-(4-(2-chloro-4-fluorophenyl)-2-oxo-2H...)
Affinity DataIC50: 100nMAssay Description:The ability of some compounds of the present invention to inhibit POLRMT were determined in a homogeneous TR-FRET Assay using high-throughput screeni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent