BDBM784207 7-(((R)-1-((R)-3-(dimethylamino)pyrrolidin-1-yl)-1-oxopropan-2-yl)oxy)-4-(o-tolyl)isoquinolin-1(2H)-one::US20250340516, Example 64

SMILES Cc1ccccc1-c1c[nH]c(=O)c2cc(O[C@H](C)C(=O)N3CC[C@@H](N(C)C)C3)ccc12

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 784207   

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784207(7-(((R)-1-((R)-3-(dimethylamino)pyrrolidin-1-yl)-1...)
Affinity DataIC50: 200nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent