BDBM784215 7-(2,2-difluoroethoxy)-4-(2-(hydroxymethyl)-6-methylphenyl)isoquinolin-1(2H)-one::US20250340516, Example 72

SMILES Cc1cccc(CO)c1-c1c[nH]c(=O)c2cc(OCC(F)F)ccc12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 784215   

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784215(7-(2,2-difluoroethoxy)-4-(2-(hydroxymethyl)-6-meth...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent