BDBM784936 3-(3-ethoxy-2,4-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 50

SMILES CCOc1c(F)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F

InChI Key InChIKey=ORWXJPCSZPDKMM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 784936   

LigandChemical structure of BindingDB Monomer ID 784936BDBM784936(3-(3-ethoxy-2,4-difluorophenyl)-6-fluoro-1-benzoth...)
Affinity DataIC50: 490nMAssay Description:Inhibition of human BDK using LBD-Tev-PhosphoPep/Lipoyl as substrate preincubated for 15 mins followed by substrate/ATP addition and measured after 9...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 784936BDBM784936(3-(3-ethoxy-2,4-difluorophenyl)-6-fluoro-1-benzoth...)
Affinity DataIC50: 490nMAssay Description:BCKDK activity was monitored by phosphorylation of a HIS-tagged fusion BCKDHE1α-E2 substrate protein as described above and was detected using a time...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 784936BDBM784936(3-(3-ethoxy-2,4-difluorophenyl)-6-fluoro-1-benzoth...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of BDK in human skeletal myocyte using BCKDHA as substrate assessed as inhibition of substrate phosphorylation incubated for 60 mins by Al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed