BDBM785344 US12466840, Example Ex-1

SMILES F/C=C\9CN1CCC[C@@]1(COc6nc7c5c(nc(c3c(C2CC2)c(Cl)cc4[nH]ncc34)c(F)c5n6)OC[C@@H]8COCCCN78)C9

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 785344   

TargetGTPase KRas [G12D](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 0.670nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G12R](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G12S](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G12A](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas(Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 0.870nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G12V](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G13D](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 3.70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G12C](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 6.90nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase HRas(Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 1.11E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase NRas(Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 1.11E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent