BDBM785348 US12466840, Example Ex-5

SMILES F/C=C1\CN2CCC[C@@]2(COc2nc3c4c(nc(-c5c(C6(F)CC6)c(Cl)cc6[nH]ncc56)c(F)c4n2)OC[C@@H]2COCCCN32)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 785348   

TargetGTPase KRas [G12D](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas(Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G12S](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 0.770nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G12A](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 0.830nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 0.970nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G12V](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 0.980nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G13D](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G12R](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase KRas [G12C](Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 3.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase HRas(Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 4.68E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent

TargetGTPase NRas(Human)
Merck Sharp & Dohme LLC

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 1.11E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details US Patent