BDBM7873 2-chloro-1-phenylethan-1-one::CHEMBL105712::Halomethyl Phenyl Ketone deriv. 21

SMILES ClCC(=O)c1ccccc1

InChI Key InChIKey=IMACFCSSMIZSPP-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 7873   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM7873(2-chloro-1-phenylethan-1-one | CHEMBL105712 | Halo...)
Affinity DataKi:  4.80E+5nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily A member 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM7873(2-chloro-1-phenylethan-1-one | CHEMBL105712 | Halo...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Human)
Instituto De Qui£?Mica Medica-Csic

Curated by ChEMBL
LigandPNGBDBM7873(2-chloro-1-phenylethan-1-one | CHEMBL105712 | Halo...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of GSK3beta using GS1 as substrate and [gamma-32P]ATP after 20 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Human)
Instituto De Qui£?Mica Medica-Csic

Curated by ChEMBL
LigandPNGBDBM7873(2-chloro-1-phenylethan-1-one | CHEMBL105712 | Halo...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of glycogen synthase kinase-3 beta (unknown origin) using GS-1 as substrate after 20 mins by scintillation counting analysis in presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta [7-25](Rabbit)
Instituto De Quimica Medica (Csic)

LigandPNGBDBM7873(2-chloro-1-phenylethan-1-one | CHEMBL105712 | Halo...)
Affinity DataIC50:  5.00E+4nMT: 37°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed