BDBM787991 N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methyl-5-(2-carbonyl-1-(3,3,3-trifluoropropyl)-2'',3'',5'',6''-tetrahydrospiro[dihydroindole-3,4''-pyran]-6-yl)benzamide::US12473298, Compound 14

SMILES CCN(c5cc(c1ccc2c(c1)N(CCC(F)(F)F)C(=O)C23CCOCC3)cc(C(=O)NCc4c(C)cc(C)[nH]c4=O)c5C)C6CCOCC6

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 787991   

TargetHistone-lysine N-methyltransferase EZH2 [Y641N](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787991BDBM787991(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.150nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787991BDBM787991(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.290nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787991BDBM787991(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787991BDBM787991(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.650nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent