BDBM788009 Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methylphenyl)-1-methyl-2-carbonylspiro[dihydroindole-3,4''-piperidine]-1''-carboxylate::US12473298, Compound 32

SMILES CCN(c5cc(c1ccc2c(c1)N(C)C(=O)C23CCN(C(=O)OC)CC3)cc(C(=O)NCc4c(C)cc(C)[nH]c4=O)c5C)C6CCOCC6

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 788009   

TargetHistone-lysine N-methyltransferase EZH2 [Y641N](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788009BDBM788009(Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydro...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788009BDBM788009(Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydro...)
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788009BDBM788009(Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydro...)
Affinity DataIC50: 0.650nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788009BDBM788009(Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydro...)
Affinity DataIC50: 0.790nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent