BDBM788015 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-5-(1-ethyl-2'',3'',5'',6''-tetrahydrospiro[dihydroindole-3,4''-pyran]-6-yl)-2-methylbenzamide::US12473298, Compound 38

SMILES CCN1CC2(CCOCC2)c2ccc(-c3cc(C(=O)NCc4c(C)cc(C)[nH]c4=O)c(C)c(N(CC)C4CCOCC4)c3)cc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 788015   

TargetHistone-lysine N-methyltransferase EZH2 [Y641N](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788015BDBM788015(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.280nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788015BDBM788015(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.420nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788015BDBM788015(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.720nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788015BDBM788015(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent