BDBM788020 3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)amino)-5-(2,2'',3,3'',5'',6''-hexahydrospiro[indene-1,4-pyran]-5-yl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide::US12473298, Compound 43

SMILES CCN(c1cc(-c2ccc3c(c2)CCC32CCOCC2)cc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C)C1CCOC(C)(C)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 788020   

TargetHistone-lysine N-methyltransferase EZH2 [Y641N](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788020BDBM788020(3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)am...)
Affinity DataIC50: 0.0800nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788020BDBM788020(3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)am...)
Affinity DataIC50: 0.230nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788020BDBM788020(3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)am...)
Affinity DataIC50: 0.390nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788020BDBM788020(3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)am...)
Affinity DataIC50: 0.610nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent