BDBM788035 N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-6-fluoro-2-methyl-5-(2-carbonyl-1-propyl-2'',3'',5'',6''-tetrahydrospiro[dihydroindole-3,4''-pyran]-6-yl)benzamide::US12473298, Compound 58

SMILES CCCN6C(=O)C1(CCOCC1)c5ccc(c4cc(N(CC)C2CCOCC2)c(C)c(C(=O)NCc3c(C)cc(C)[nH]c3=O)c4F)cc56

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 788035   

TargetHistone-lysine N-methyltransferase EZH2 [Y641N](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788035BDBM788035(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788035BDBM788035(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.350nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788035BDBM788035(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.470nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 788035BDBM788035(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.620nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent