BDBM789922 (17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c'':6,7-c$#8243;]tripyrazole::US20250353864, Example 7

SMILES Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 789922   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789922BDBM789922((17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-...)
Affinity DataIC50: 0.0800nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789922BDBM789922((17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789922BDBM789922((17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-...)
Affinity DataIC50: 0.480nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789922BDBM789922((17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-...)
Affinity DataIC50: 45.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789922BDBM789922((17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-...)
Affinity DataIC50: 202nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789922BDBM789922((17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-...)
Affinity DataIC50: 687nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789922BDBM789922((17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-...)
Affinity DataIC50: 898nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789922BDBM789922((17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789922BDBM789922((17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-...)
Affinity DataIC50: 2.12E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent