BDBM789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4'',3''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55

SMILES Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 789963   

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789963BDBM789963((17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexa...)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789963BDBM789963((17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexa...)
Affinity DataIC50: 0.130nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789963BDBM789963((17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexa...)
Affinity DataIC50: 0.580nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789963BDBM789963((17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexa...)
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789963BDBM789963((17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexa...)
Affinity DataIC50: 8.93nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789963BDBM789963((17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexa...)
Affinity DataIC50: 33.4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789963BDBM789963((17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexa...)
Affinity DataIC50: 35.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789963BDBM789963((17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexa...)
Affinity DataIC50: 78.3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789963BDBM789963((17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexa...)
Affinity DataIC50: 101nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789963BDBM789963((17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexa...)
Affinity DataIC50: 185nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent