BDBM789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58

SMILES Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 789965   

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 0.380nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 1.57nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetALK tyrosine kinase receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 4.79nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 7.29nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 9.29nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 11.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 49.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 160nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789965BDBM789965((10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13...)
Affinity DataIC50: 222nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent