BDBM789986 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 89

SMILES Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 789986   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 0.0600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 0.450nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 4.66nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 6.67nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 19.7nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 64nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789986BDBM789986((10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidi...)
Affinity DataIC50: 191nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent