BDBM789987 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylpiperazin-1-yl)ethyl]- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 90

SMILES Cc1c2c(nn1CCN1CCN(C)CC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 789987   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789987BDBM789987((10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylp...)
Affinity DataIC50: 0.0600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789987BDBM789987((10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylp...)
Affinity DataIC50: 0.810nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789987BDBM789987((10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylp...)
Affinity DataIC50: 1.02nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789987BDBM789987((10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylp...)
Affinity DataIC50: 4.65nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789987BDBM789987((10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylp...)
Affinity DataIC50: 11.6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789987BDBM789987((10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylp...)
Affinity DataIC50: 17.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789987BDBM789987((10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylp...)
Affinity DataIC50: 81.8nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent