BDBM789989 (10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)methyl]- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4'',3''- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 92

SMILES CN1CCN(Cc2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 789989   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789989BDBM789989((10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)me...)
Affinity DataIC50: 0.410nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789989BDBM789989((10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)me...)
Affinity DataIC50: 3.26nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789989BDBM789989((10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)me...)
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789989BDBM789989((10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)me...)
Affinity DataIC50: 6.34nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789989BDBM789989((10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)me...)
Affinity DataIC50: 6.65nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789989BDBM789989((10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)me...)
Affinity DataIC50: 7.95nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789989BDBM789989((10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)me...)
Affinity DataIC50: 14.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent