BDBM789991 (10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4'',3''- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 94

SMILES CN(C)Cc1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 789991   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789991BDBM789991((10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5...)
Affinity DataIC50: 0.820nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789991BDBM789991((10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5...)
Affinity DataIC50: 5.75nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789991BDBM789991((10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5...)
Affinity DataIC50: 9.99nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789991BDBM789991((10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5...)
Affinity DataIC50: 14.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789991BDBM789991((10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5...)
Affinity DataIC50: 17.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789991BDBM789991((10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5...)
Affinity DataIC50: 17.6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 789991BDBM789991((10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5...)
Affinity DataIC50: 44.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent