BDBM790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3'',4''-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109

SMILES CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790002   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Affinity DataIC50: 0.850nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Affinity DataIC50: 15.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Affinity DataIC50: 38nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Affinity DataIC50: 47.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Affinity DataIC50: 152nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Affinity DataIC50: 165nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Affinity DataIC50: 298nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790002BDBM790002((10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahy...)
Affinity DataIC50: 856nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent