BDBM790004 (17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 111

SMILES CCN1CCOc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2C1

InChI Key

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 790004   

LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 0.390nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 1.91nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 3.29nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 8.04nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 9.18nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 16.8nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 63.3nMAssay Description:Table 1: The inhibitory activities against EGFR WT, EGFR (D770_N771insNPG), EGFR Δ746-750 mutant, EGFR Δ746-750/C797S mutant, EGFR L858R mutant, EGFR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details