BDBM790004 (17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4'',3''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 111

SMILES CCN1CCOc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 790004   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 0.390nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 1.91nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 3.29nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 8.04nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 9.18nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 16.8nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790004BDBM790004((17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-...)
Affinity DataIC50: 63.3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent