BDBM790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4'',3''- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112

SMILES CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790005   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 0.0400nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 0.170nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 0.210nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 0.610nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 0.980nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 1.12nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 1.31nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 2.75nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790005BDBM790005((10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,...)
Affinity DataIC50: 8.28nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent