BDBM790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3'',4''-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122

SMILES Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790015   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 0.150nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 1.46nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 2.09nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 6.79nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 7.45nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 11.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 21.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 58nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790015BDBM790015((10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16...)
Affinity DataIC50: 94.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent