BDBM790020 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3'',4''- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 127

SMILES Cc2nn(C[C@@H](C)O)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 790020   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790020BDBM790020((2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,1...)
Affinity DataIC50: 0.150nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790020BDBM790020((2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,1...)
Affinity DataIC50: 0.430nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790020BDBM790020((2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,1...)
Affinity DataIC50: 0.850nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790020BDBM790020((2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,1...)
Affinity DataIC50: 1.81nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790020BDBM790020((2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,1...)
Affinity DataIC50: 2.82nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790020BDBM790020((2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,1...)
Affinity DataIC50: 11.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790020BDBM790020((2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,1...)
Affinity DataIC50: 25.6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent