BDBM790024 (10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4'',3''- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 131

SMILES CN1CCN(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 790024   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790024BDBM790024((10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,...)
Affinity DataIC50: 0.570nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790024BDBM790024((10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,...)
Affinity DataIC50: 1.65nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790024BDBM790024((10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,...)
Affinity DataIC50: 1.90nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790024BDBM790024((10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,...)
Affinity DataIC50: 4.02nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790024BDBM790024((10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,...)
Affinity DataIC50: 4.09nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790024BDBM790024((10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,...)
Affinity DataIC50: 6.79nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790024BDBM790024((10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,...)
Affinity DataIC50: 17.7nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent