BDBM790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4'',3''- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132

SMILES Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790025   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 0.0200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 0.280nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 20.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 35.3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 39.4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 67nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 157nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 284nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790025BDBM790025((10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahy...)
Affinity DataIC50: 721nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent