BDBM790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142

SMILES CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790033   

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 1.11nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 1.29nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 1.32nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 1.83nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 2.14nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 5.91nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 11.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 13.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 16.7nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790033BDBM790033(2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propa...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent