BDBM790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3'',4''-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160

SMILES CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790044   

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 0.220nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 0.410nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 1.08nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 1.42nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 13.6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 19.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 34.4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 38.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 63nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790044BDBM790044((10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13...)
Affinity DataIC50: 246nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent