BDBM790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163

SMILES C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 790047   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 0.0600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 0.280nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 0.630nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 0.850nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 0.860nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetALK tyrosine kinase receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 1.13nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 4.72nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 7.33nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 8.20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 29.6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 52nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790047BDBM790047({[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,...)
Affinity DataIC50: 215nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent