BDBM790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164

SMILES CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790048   

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 0.390nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 0.590nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 0.75nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 1.76nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 3.23nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 16.7nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 20.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 33.4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 95.3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 220nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790048BDBM790048((10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)m...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent