BDBM790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3'',4''- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165

SMILES CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790049   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 0.0200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 0.440nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 0.470nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 2.33nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 4.84nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 6.08nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 19nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 28.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790049BDBM790049((10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11...)
Affinity DataIC50: 72.4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent