BDBM790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3'',4''-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167

SMILES Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790051   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 0.230nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 0.380nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 0.550nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 3.42nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 8.89nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 13.6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 23.8nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 35.7nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 47.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 108nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790051BDBM790051(n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-tri...)
Affinity DataIC50: 123nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent