BDBM790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4'',3''-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170

SMILES Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790054   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 0.380nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 0.430nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 25.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 30.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 36.6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 116nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 310nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 329nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 908nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790054BDBM790054((10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent