BDBM790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4'',3''-n][1,4]oxazacyclopentadecine::US20250353864, Example 174

SMILES CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790058   

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 0.160nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 0.210nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 0.510nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 4.88nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 10.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 27.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 127nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 128nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 133nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 752nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790058BDBM790058((10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12...)
Affinity DataIC50: 996nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent