BDBM790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3'',4''-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199

SMILES CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790074   

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 1.05nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 1.79nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 2.29nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 19.3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 42.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 43.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 64.4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 87.8nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 147nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790074BDBM790074(2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)...)
Affinity DataIC50: 1.28E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent