BDBM790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203

SMILES C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790077   

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 0.110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 0.120nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 0.140nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 0.170nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 0.230nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 0.230nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 0.650nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 0.720nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 0.780nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 1.59nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 151nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent