BDBM790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215

SMILES CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 790086   

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 0.890nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 1.49nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 1.71nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 1.93nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 2.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetALK tyrosine kinase receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 2.58nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 3.33nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 3.75nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 9.08nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790086BDBM790086((2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,...)
Affinity DataIC50: 964nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent