BDBM790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227

SMILES CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790097   

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 0.840nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 2.59nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 4.63nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 4.90nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 6.82nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 9.86nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 60.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 167nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 251nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790097BDBM790097((2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(pro...)
Affinity DataIC50: 471nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent