BDBM790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229

SMILES CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790099   

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 1.24nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 1.94nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 4.05nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 4.07nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 7.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 24.8nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 38.6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 59.6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 68.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 131nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790099BDBM790099((2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimeth...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent