BDBM790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232

SMILES CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 790100   

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 0.0800nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 0.110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 0.130nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 0.220nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 0.410nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 0.450nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 0.550nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 0.770nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetALK tyrosine kinase receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 1.39nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 1.49nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 42nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent