BDBM790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252

SMILES CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 790109   

TargetDual specificity protein kinase CLK2(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 0.420nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK1(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 0.830nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 1.31nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK4(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 1.59nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 1.91nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 2.29nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 2.38nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 4.74nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 5.35nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 15.7nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790109BDBM790109(2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 168nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent