BDBM790110 2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 253

SMILES CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 790110   

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790110BDBM790110(2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 0.75nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790110BDBM790110(2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 1.63nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790110BDBM790110(2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 1.66nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790110BDBM790110(2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 1.98nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790110BDBM790110(2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 2.55nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790110BDBM790110(2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 3.21nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
BLOSSOMHILL THERAPEUTICS, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 790110BDBM790110(2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy...)
Affinity DataIC50: 5.27nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent