BDBM792936 2-(4-Phenoxy-phenyl)-8-[1-(4,4,4-trifluoro-but-2-enoyl)-piperidin-4-yl]-5,6,7,8-tetrahydro-imidazo[1,2-b]pyridazine-3-carboxamide::US12552798, Example 10

SMILES NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nc2n1NCCC2C1CCN(C(=O)/C=C/C(F)(F)F)CC1

InChI Key InChIKey=MESPQNZJTUXZNR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 792936   

TargetTyrosine-protein kinase BTK(Human)
Henan Zhiwei Biomedicine Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 792936BDBM792936(2-(4-Phenoxy-phenyl)-8-[1-(4,4,4-trifluoro-but-2-e...)
Affinity DataIC50: 8.20nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/29/2026
Entry Details US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Henan Zhiwei Biomedicine Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 792936BDBM792936(2-(4-Phenoxy-phenyl)-8-[1-(4,4,4-trifluoro-but-2-e...)
Affinity DataIC50: 49.5nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/29/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
Henan Zhiwei Biomedicine Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 792936BDBM792936(2-(4-Phenoxy-phenyl)-8-[1-(4,4,4-trifluoro-but-2-e...)
Affinity DataIC50: 1.93E+3nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/29/2026
Entry Details US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Henan Zhiwei Biomedicine Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 792936BDBM792936(2-(4-Phenoxy-phenyl)-8-[1-(4,4,4-trifluoro-but-2-e...)
Affinity DataIC50: 1.08E+4nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/29/2026
Entry Details US Patent