BDBM792948 (E)-2-(4-phenoxyphenyl)-8-(1-(4,4,4-trifluorobut-2-enoyl)azetidin-3-yl)-5,6,7,8-tetrahydroimidazo[1,2-b]pyridazine-3-carboxamide::US12552798, Example 20

SMILES NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nc2n1NCCC2C1CN(C(=O)/C=C/C(F)(F)F)C1

InChI Key InChIKey=NDVGPLFNMMCFAB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 792948   

TargetTyrosine-protein kinase BTK(Human)
Henan Zhiwei Biomedicine Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 792948BDBM792948((E)-2-(4-phenoxyphenyl)-8-(1-(4,4,4-trifluorobut-2...)
Affinity DataIC50: 8nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/29/2026
Entry Details US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Henan Zhiwei Biomedicine Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 792948BDBM792948((E)-2-(4-phenoxyphenyl)-8-(1-(4,4,4-trifluorobut-2...)
Affinity DataIC50: 70.3nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/29/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
Henan Zhiwei Biomedicine Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 792948BDBM792948((E)-2-(4-phenoxyphenyl)-8-(1-(4,4,4-trifluorobut-2...)
Affinity DataIC50: 3.24E+3nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/29/2026
Entry Details US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Henan Zhiwei Biomedicine Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 792948BDBM792948((E)-2-(4-phenoxyphenyl)-8-(1-(4,4,4-trifluorobut-2...)
Affinity DataIC50: 8.65E+3nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/29/2026
Entry Details US Patent