BDBM793705 (2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-N-(2-((R)-2,3-dihydroxypropoxy)pyridin-4-yl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamide 2::US20260055088, Example 2

SMILES COc1c([C@H]2[C@H](C(=O)Nc3ccnc(OC[C@H](O)CO)c3)O[C@@](C)(C(F)(F)F)[C@H]2C)ccc(F)c1F

InChI Key InChIKey=SGYCRHNKOCUONF-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 793705   

TargetSodium channel protein type 8 subunit alpha(Human)
Jiangsu Hengrui Pharmaceuticals Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 793705BDBM793705((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-N-(...)
Affinity DataIC50: 2.89nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2026
Entry Details US Patent