BDBM793717 (2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-N-(2-((Z)—N''-methylcarbamimidoyl)pyridin-4-yl)-5-(trifluoromethyl)tetrahydrofuran-2-carboxamide 21::US20260055088, Example 21

SMILES C/N=C(N)c1cc(NC(=O)[C@@H]2O[C@@](C)(C(F)(F)F)[C@@H](C)[C@H]2c2ccc(F)c(F)c2OC)ccn1

InChI Key InChIKey=JYKXZXNGKWAKRN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 793717   

TargetSodium channel protein type 8 subunit alpha(Human)
Jiangsu Hengrui Pharmaceuticals Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 793717BDBM793717((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5...)
Affinity DataIC50: 1.35nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2026
Entry Details US Patent